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S. Mark Tompkins, Ph.D.

Associate Professor

Infectious Diseases

Office: Animal Health Research Center, Rm Rm. 112B   
Voice: 706-542-4716
: smt@uga.edu

Education

Ph.D. Immunology, Emory University, Atlanta, GA 1997

B.S. Microbiology, University of Illinois, Urbana, IL 1990

Research Interests

Antiviral Research

Dr. Tompkins' research interests focus on understanding transmission and pathogenicity of zoonotic influenza virus infection and development of novel approaches to vaccination and the prevention and treatment of viral infections. This utilizes a variety of animal models and disease hosts including mice, ferrets, cats, and swine. Studies include understanding transmission and pathogenic potential of avian influenza virus field isolates, surveillance of non-contemporary mammalian influenza viruses, mutagenesis of influenza viruses, novel recombinant vaccine and vaccine delivery development, therapeutic applications of RNA interference, and understanding the role of microRNAs in infectious disease and neoplasia. Related to this he has contributed to genome-wide screening for host genes involved in viral (influenza, measles, RSV, polio, Hendra) replication using siRNA libraries. He has also worked on a variety of approaches for development of human antibodies for prevention and treatment of infectious diseases. Recent studies explore the innate immune response to viral infection is different host species, including human, swine, mouse, feline, alligator, and bat. As a Fulbright Scholar, he focused on identification of drug targets and development of novel anti-viral drugs for Hendra virus and other emerging infectious diseases.

Of Note

Post-doctoral Experience
Postdoctoral Associate, Immunology, Northwestern University Medical School, Chicago, IL, 1997-2002
Postdoctoral Associate, Virology/Immunology, CBER/FDA, Bethesda, MD, 2002-2005
Honors and Awards
2012-2013 2012 Fulbright Senior Scholar, Australian-American Fulbright Commission

Fellows Award for Research Excellence (FARE), National Institutes of Health Fellows Committee, the Scientific Directors, the Office of Research on Women's Health, and the NIH Office of Education, Bethesda, MD. Protection against lethal influenza virus challenge by RNA interference in vivo, 2004

John M. Bowen Award for Excellence in Animal/Biomedical Research, University of Georgia College of Veterinary Medicine, 2007

Selected Publications

Mooney, A., Li, Z., Gabbard, J.D., He, B., and S.M. Tompkins. 2013 Recombinant PIV5 vaccine protects against HPAI H5N1 infection when delivered intranasally or intramuscularly. J. Virol. 87(1):363-71. PMID: 23077318

Perwitasari, O., Bakre, A., Tompkins, S.M., and R.A. Tripp. 2013 siRNA Genome Screening Approaches to Therapeutic Drug Repositioning. Pharmaceuticals. 6(2):124-160.

Perwitasari, O. Torrecilhas, A.C., Yan, X., Johnson, S., White, C., Tompkins, S.M., and R.A. Tripp. 2013 Targeting Cell Division Cycle 25 Homolog B (CDC25B) to Regulate Influenza Virus Replication. J Virol. 2013 Oct 9. [Epub ahead of print] PMID: 24109234

McCutcheon, K.M., Gray, J., Chen, N.Y., Liu, K., Park, M., Ellsworth, S., Tripp, R.A., Tompkins, S.M., Johnson, S.K., Samet, S., Pereira, L., Kauvar, L.M. 2014 Multiplexed screening of natural humoral immunity identifies antibodies at fine specificity for complex and dynamic viral targets. MAbs. 6(2):460-73. PMID: 24492306.

Fox J.M., Sage L.K., Poore, S., Johnson, S., Tompkins S.M., Tripp R.A. Drug analog inhibition of indoleamine 2,3-dioxygenase (IDO) activity modifies pattern recognition receptor expression and proinflammatory cytokine responses early during influenza virus infection. J Leukoc Biol. 2014 May 5. PMID: 24799604