Natarajan Kannan, Ph.D.

Assistant Professor

Biochemistry and Molecular Biology

Office: Life Sciences Bldg., Rm Rm. A318A   
Voice: 706-542-7326
: kannan@bmb.uga.edu


Ph.D. Biophysics, Indian Institute of Science, Bangalore, India 2000

Research Interests

Evolutionary Systems Biology

Our lab focuses on understanding the regulatory complexity of signaling proteins such as protein kinases, phosphatases and glycosidases using systems biology approaches. Currently, we are focusing on the protein kinase family, which has evolved numerous regulatory mechanisms to control important cellular processes in the eukaryotic cell. Abnormal activation or regulation of protein kinase activity is implicated in many human cancers. We are interested in understanding the regulatory mechanisms of the protein kinase machinery by extracting the analyzing the evolutionary information embedded in genomic sequences. Specifically, we are using rigorous statistical methods to measure the evolutionary constraints acting on protein kinase sequences and analyzing these constraints in light of structural and biochemical data to formulate and test hypotheses regarding the regulation of these proteins in signaling pathways. We believe that such an integrative “top-down” approach will complement existing “bottom-up” approaches to study the protein kinase family, and provide new therapeutic strageties for targeting abnormally regulated kinases in human cancers.

Of Note

Post-doctoral Experience
Post-Doctoral Fellow in Bioinformatics, Cold Spring Harbor Lab (CSHL), NY
Post-Doctoral Fellow in Biochemistry, University of California San Diego, CA
Honors and Awards
2001 Indian National Science Academy Young Scientist Award
2002 Cold Spring Harbor Laboratory Postdoctoral Fellow Award
2009 Georgia Cancer Coalition Distinguished Cancer Scholar Award
2010 American Cancer Society Research Scholar Award
2011 ACS-Illumina Research Acceleration Award

Selected Publications

Gosal G, Kochut K and Kannan N*. ProKinO: An ontology for integrative analysis of protein kinases in cancer. PLoS ONE, 2011;6(12):e28782

Talevich E, Mirza A and Kannan N*. Structural and evolutionary divergence of
eukaryotic protein kinases in Apicomplexa. BMC Evol. Biol. 2011 Nov 2; 11(1):321

Mustafa M, Mirza M and Kannan N*. Conformational regulation of the EGFR kinase core by the Juxtamembrane and COOH-terminal tail. Proteins, 2011; Jan; 79(1):99-114

Mirza M, Mustafa M, Talevich E and Kannan N*. Co-conserved features associated with cis regulation of ErbB receptor tyrosine kinases. PLoS ONE, 2010; Dec 13; 5(12):e1431

Kang N, Jun AH, Bhutia YD, Kannan N, Unadkat JD, Govindarajan R*. Human
equilibrative nucleoside transporter-3 (hENT3) spectrum disorder mutations impair nucleoside transport, protein localization, and stability. JBC. 2010; 285(36):28343-53