David Munn, M.D.


School of Medicine

Augusta University, Augusta, GA

Voice: 706-721-7141
: dmunn@gru.edu


M.D. , Medical College of Georgia, Augusta, GA 1984

B.A. , Mercer University, Macon, GA 1978

Research Interests

Regulation of T Cell Activation

Study of the regulation of T cell activation by antigen-presenting cells (macrophages and dendritic cells). A major focus of the laboratory is the immunoregulatory role of tryptophan metabolism via the enzyme indoleamine 2,3-dioxygenase (IDO) expressed by antigen-presenting cells. Active projects include: (1) the role of IDO-expressing dendritic cells in maintaining tolerance to self in the peripheral T cell compartment; (2) cell cycle regulation and anergy induction in T cells via IDO-induced activation of the GCN2-kinase pathway; (3) preclinical and clinical development of IDO inhibitor drugs for treatment of patients with cancer and HIV.

Selected Publications

Munn DH, Sharma MD, Baban B, Harding HP, Zhang Y, Ron D, Mellor AL. GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3 dioxygenase. Immunity 22:633-642 (2005)

Potula R, Poluektova L, Knipe B, Chrastil J, Heilman D, Dou H, Takikawa O, Munn DH, Gendelman HE PersidskyY. Inhibition of Indoleamine 2,3-dioxygenase (IDO) enhances elimination of virus infected macrophages in animal model of HIV-1 encephalitis. Blood 106:2382-2390 (2005)

Munn DH, Sharma MD, Hou D, Baban B, Lee JR, Antonia SJ, Messina JL, Chandler P, Koni PA, Mellor AL. Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes. J Clin Invest 114:280-190 (2004)

Munn DH, Mellor AL. IDO and tolerance to tumors. Trends Molec Med 10:15-18 (2004)

Mellor AL, Munn, DH. Indoleamine 2,3-dioxygenase expression in dendritic cells: tolerance and tryptophan catabolism. Nature Rev Immunol 25:563-565 (2004)