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Binghe Wang, Ph.D.

Regents Professor and GRA Eminent Scholar

Chemistry

Georgia State University, Atlanta, GA 30302-3965

Office:   
Voice: 404-413-5544
: wang@gsu.edu

Education

Ph.D. Medicinal Chemistry, University of Kansas, Lawrence, KS 1991

B.S. Medicinal Chemistry, Beijing Medical University, Beijing, China 1982

Research Interests

Drug Delivery
Drug Design

Research interests are in the areas of: (1) Drug Design: anticancer, anti-infectives, anti-inflammation, immune regulation; (2) Drug delivery: prodrug, receptor-mediated drug delivery, drug-release chemistry; (3) New diagnostics, fluorescent sensors, and molecular probes; (4) Disease biomarkers including carbohydrate biomarkers.

Of Note

Post-doctoral Experience
Post-doctoral Research Associate, Department of Pharmaceutical Chemistry, University of Kansas School of Pharmacy, 1992-1993
Post-doctoral Research Associate, Department of Chemistry, University of Arizona, 1992
Honors and Awards
Georgia Research Alliance Eminent Scholar in Drug Discovery
Georgia Cancer Coalition Distinguished Cancer Scientist

Selected Publications

Wang, D.; Merlin, D.; Viennois, E.; Ji, K.; Damera, K.; Draganov, A.; Zheng, Y.; Dai, C. Wang, B. “Caging and Releasing a Gasotransmitter: A Click-and-Release Approach to CO Prodrugs” Chem. Commun. 2014, 50, 15890-15893

Cheng, Y.; Dai, C.; Peng, H.; Chen, W.; Ni, N.; Ke, B.; Wang, B. “Rapid and Specific Post-synthesis Modification of DNA via a Bio-orthogonal Condensation of 1,2-Aminothiols with 2-Cyanobenzothiazole” Chem.-Eur. J. 2013, 19, 4036-4042. PMID:23447494

Cui, J.; Jin, J.; Hsieh, Y.; Yang, H.; Ke, B.; Tai, P.C.; Wang, B. “Design, Synthesis and Biological Evaluation of RB Analogs as SecA Inhibitors” ChemMedChem, 2013, 8, 1384-1393. PMID:23794293

Chen, W.; Wang, D.; Dai, C.; Hamelberg, D. Wang, B. “Clicking 1,2,4,5-Tetrazine and Cyclooctynes with Tunable Reaction Rates” Chem. Commun. 2012, 48, 1736-1738 PMID: 22159330

Reid, S.; Devi, N.S.; Jabbar, A.A.; Kaluz, S.; Van Meir, E.; Wang, B. “Design, Synthesis, and Evaluation of Novel HIF-1 Inhibitors” J. Med. Chem. 2011, 54, 8471−8489. PMID: 22032632