Quicklinks

Arthur Roberts, Ph.D.

Assistant Professor

Pharmaceutical and Biomedical Sciences

Office: Pharmacy South, Rm Rm. 424   
Voice: 706-542-7787
: audie@uga.edu

Education

Ph.D. Biochemistry, Washington State University, Pullman, WA 1982

B.S. Biochemistry, University of New Mexico, Albuquerque, NM 1996

Research Interests

Multiple-drug Transporters

The Roberts lab is interested in studying the interaction of drugs with multiple-drug resistance transporters and drug-metabolizing UDP-glucuronosyltransferases. These proteins play major roles in cancer resistance, in neurological diseases (e.g. Alzheimer’s disease and Parkinson’s) and in mitigating the effects of environmental pollutants. Using human proteins isolated from genetically engineered yeast or bacteria, one goal is to develop structural biology tools to rapidly and accurately predict the effects of drugs and toxins before they end up in people. These tools will allow them to design next generation drugs that are more effective and have fewer side effects than current medications. Another goal is to develop advanced NMR and computational methods to probe the effects of drugs and toxins in whole cells. These techniques will allow them to probe the complex interplay between transporters, receptors and enzymes during drug and metabolite processing. In addition to these research goals, the Roberts lab is developing creative and novel teaching methods to train students of different skill levels in his laboratory. Achieving these research and teaching goals will not only advance medicine and improve drug therapies, but will prepare students well for industry or academic careers in the 21st century.

Of Note

Post-doctoral Experience
Postdoctoral Research Associate, University of Washington, Seattle, WA., 2003-2008
Graduate Research Assistant/Postdoctoral Research Associate, Washington State University, Pullman, WA., 1996-2003
Honors and Awards
2011, Best Speech Award from Toastmasters International-Stadium Chapter (San Diego, CA)
2010, Best Table Topics and Best Speech Awards from Toastmasters International-Stadium Chapter (San Diego, CA)
2001, Best Speaker Award Western Photosynthesis Conference (Monterey, CA

Selected Publications

Roberts, A.G., Sjögren, S.E.A., Fomina, N., Vuc, K.T., Almutairi, A. and Halpert, J.R. (2011) NMR-derived models of amidopyrine and its metabolites complexed to rabbit cytochrome P450 2B4 reveals a structural mechanism of sequential N-dealkylation. Biochemistry 50 2123-2134

Roberts, A.G., Yang, J., Halpert, J.R., Nelson, S.D., Thummel, K.T., Atkins, W.M. (2011) The structural basis for homotropic and heterotropic cooperativity of midazolam metabolism by human cytochrome P450 3A4. Biochemistry 50, 10804-10818

Roberts, A.G., Díaz, M.D., Lampe, J.N., Shireman, L.M., Grinstead, J.S., Dabrowski, M.J., Pearson, J.T., Bowman, M.K., and Atkins, W.M., Campbell, A. P. (2006) NMR studies of ligand binding to P450eryF provides insight into the mechanism of cooperativity. Biochemistry 45(6): p. 1673-1684